Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water.,
敏感性
对热和光线敏感
存贮条件
储存温度: -20 ℃;充氩保存
密度
1.1200
荧光
否
IC50
否
pK Values
否
描述
产品介绍
Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type (v-type) H+ ATPase) and belongs to a class of membrane ATPase inhibitors. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.
用途
A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase
生化机理
A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
021-54720761
021-54720761
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